Trelagliptin

Product Name: Trelagliptin
CAS No.: 865759-25-7
Chemical Name: Trelagliptin
Synonyms: Trilagliptin;YR-472;CS-926;Zafatek);Trelagliplin;Trelagliptin;Glass acid trigram;Trelagliptin, >=98%;SYR472 Trelagliptin;Trelagliptin(syr472)
CBNumber: CB52628490
Molecular Formula: C18H20FN5O2
Formula Weight: 357.38
MOL File: 865759-25-7.mol

More

Less

Trelagliptin Property

Boiling point:: 519.0±60.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥11.6 mg/mL in DMSO; ≥3.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥93.8 mg/mL in H2O
form: solid
pka: 9.88±0.20(Predicted)
InChI: InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
InChIKey: IWYJYHUNXVAVAA-OAHLLOKOSA-N
SMILES: C(#N)C1=CC=C(F)C=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 18504
Product name: Trelagliptin
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 18504
Product name: Trelagliptin
Purity: ≥98%
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 18504
Product name: Trelagliptin
Purity: ≥98%
Packaging: 10mg
Price: $388
Updated: 2024/03/01

TRC

Product number: T718780
Product name: Trelagliptin
Packaging: 10mg
Price: $375
Updated: 2021/12/16

TRC

Product number: A627965
Product name: (S)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile
Packaging: 2.5mg
Price: $430
Updated: 2021/12/16

More

Less

Trelagliptin Chemical Properties,Usage,Production

Uses

Trelagliptin is a highly selective, long-acting dipeptidyl peptidase IV (DPP-4) inhibitor. This inhibitor provides sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes.

Definition

ChEBI: Trelagliptin is a member of benzenes and a nitrile.

Biological Activity

trelagliptin (syr-472) is a selective inhibitor of dpp-4 and is developed for the treatment of type 2 diabetes mellitus (t2dm) [1].dipeptidyl peptidase (dpp)-4 also known as adenosine deaminase complexing protein 2 or cd26 is an antigenic enzyme that expressed on the surface of most cell types and plays an important role in regulating immune system, signal transduction and apoptosis [2, 3].trelagliptin (syr-472) is a potent dpp-4 inhibitor and can be administered once weekly which unlike its other class approved agents that be taken once daily [1]. in japan,

target

DPP-4

References

[1]. mckeage, k., trelagliptin: first global approval. drugs, 2015. 75(10): p. 1161-4.
[2]. inagaki, n., et al., once-weekly trelagliptin versus daily alogliptin in japanese patients with type 2 diabetes: a randomised, double-blind, phase 3, non-inferiority study. lancet diabetes endocrinol, 2015. 3(3): p. 191-7.
[3]. inagaki, n., et al., syr-472, a novel once-weekly dipeptidyl peptidase-4 (dpp-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. lancet diabetes endocrinol, 2014. 2(2): p. 125-32.

Trelagliptin Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Trelagliptin Suppliers

China 220 India 5 United Kingdom 1 United States 13 Global 239

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

More

Less

View Lastest Price from Trelagliptin manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Trelagliptin 865759-25-7
Price: US $65.00-650.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-30

PNP Biotech Co. Ltd

Product: Trelagliptin 865759-25-7
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%-99%
Supply Ability: Inquiry
Release date: 2022-10-17

Henan Bao Enluo International TradeCo.，LTD

Product: Trelagliptin 865759-25-7
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-05-12

865759-25-7, TrelagliptinRelated Search:

Trelagliptin Impurity 5 TrifluoroMethyl Dechloro Trelagliptin Impurity X (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzoic acid Trelagliptin succinate Trelagliptin Impurity 20 Trelagliptin IMpurity Icotinib Saxagliptin Pregabalin Ibrutinib Metformin Troglitazone Sofosbuvir Entospletinib (GS-9973) NVP-ADW742 ABT 263 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

Trelagliptin(syr472)

Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H) -pyrimidinyl]methyl]-4-fluoro-

Trelagliptin (R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile

(S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile

Trelagliptin Isomer Impurity

Trelagliptin, >=98%

Trelagliptin free base

Trelagliptin

1-(2-broMo-5-fluorobenzyl)-6-chloro-3-MethylpriMidine-2,4(1H, 3H)-dione

Trelagliplin

(R)-2-[[6-(3-AMinopiperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl]Methyl]-4-fluorobenzonitrile

Trelagliptin impurity G

YR-472

(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile(Trelagliptin)

(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2

4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile(Trelagliptin)

CS-926

SYR472 Trelagliptin

SYR-472; SYR472; SYR 472

Glass acid trigram

Trelagliptin Impurity 83

Trelagliptin/Trelagliptin succinate

TRELAGLIPTIN CAS 865759-25-7

2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile

Zafatek)

Trilagliptin

TrelagliptinQ: What is Trelagliptin Q: What is the CAS Number of Trelagliptin Q: What is the storage condition of Trelagliptin Q: What are the applications of Trelagliptin

Benzonitrile,2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-flChemicalbookuoro-

Trelagliptin intermediate 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-

(S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile with 1/4 succinate

865759-25-7

C18H20FN5O2

API

Trelagliptin

Inhibitors